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M9490527.TXT
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1994-09-24
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Document 0527
DOCN M9490527
TI Pathogenic diversity of simian immunodeficiency viruses.
DT 9411
AU Hirsch VM; Johnson PR; Immunodeficiency Viruses Section, NIAID, NIH,
Rockville, MD; 20852.
SO Virus Res. 1994 May;32(2):183-203. Unique Identifier : AIDSLINE
MED/94346053
AB The SIV family is a diverse group of viruses that vary considerably in
pathogenesis and virulence in their natural host species or macaques.
Although the disease induced by the SIVsm subtype in particular is
remarkably similar to human AIDS, it must be remembered that this is an
experimental animal model. Therefore, although the pathogenesis of SIVsm
(and other viruses) in macaques offers an relevant animal model for
pathogenesis and vaccine trials, the interactions of these viruses in
their natural host, and virus-, or host-specific effects have been
poorly characterized. This animal model offers a unique opportunity to
study the details of the pathogenesis of immunodeficiency and to define
host and viral factors responsible for disease progression.
DE Acquired Immunodeficiency Syndrome/ETIOLOGY Animal Disease Models,
Animal DNA, Viral/GENETICS Human Macaca Phylogeny Simian Acquired
Immunodeficiency Syndrome/ETIOLOGY
SIV/CLASSIFICATION/GENETICS/*PATHOGENICITY Variation (Genetics)
Virulence/GENETICS JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).